胃肠胰神经内分泌肿瘤

别名

GEP-NEN

近两年的全球研究 84L2

2024/08 起在 Europe PMC 检索所得，按发表时间倒序显示最近 20 篇。标题未译成中文——自动翻译需要接入 LLM 服务，尚未引入。

• 2026-07综述
  Systemic therapy for gastroenteropancreatic neuroendocrine neoplasms: current landscape and future directions
  Therapeutic advances in medical oncology · DOI · Europe PMC
• 2026-06
  Evaluating the Role of Chemotherapy in Addition to Radiotherapy for High-Risk Merkel Cell Carcinoma
  Medical sciences (Basel, Switzerland) · DOI · Europe PMC
• 2026-06开放获取
  Diagnostic Yield of Fecal Immunochemical Test for Advanced Colorectal Neoplasms in Adults Under 50: A Single-Center Cohort in Taiwan
  Journal of clinical medicine · DOI · Europe PMC
• 2026-06开放获取
  Parathyroid carcinoma: from diagnostic challenges to surgical management and long-term outcomes: A single-center retrospective analysis
  Medicine · DOI · Europe PMC
• 2026-05系统综述开放获取
  Immune checkpoint inhibitor therapy for treatment of periocular Merkel cell carcinoma: A systematic review of clinical outcomes and safety
  Indian journal of ophthalmology · DOI · Europe PMC
• 2026-05开放获取
  Improved Preoperative Diagnosis of Medullary Thyroid Carcinoma Using Dual-Mode Ultrasound Radiomics
  Cancers · DOI · Europe PMC
• 2026-05开放获取
  Pan-Cancer Prognostic Analysis of NMDAR Genes Discovered Therapeutic Implications of Neuronal–Cancer Crosstalk Mediator GRIN2A for Small Cell Lung Cancer
  Biomedicines
• 2026-05病例报告
  Clinical-pathological correlation and outcomes of eyelid Merkel cell carcinoma: A series of four cases
  Archivos de la Sociedad Espanola de Oftalmologia · DOI · Europe PMC
• 2026-05开放获取
  Personalized Drug Screening and Risk Assessment in Patient-Derived Gastroenteropancreatic Neuroendocrine Neoplasms
  The Journal of clinical endocrinology and metabolism · DOI · Europe PMC
• 2026-04开放获取
  The Role of the Mesopancreas in Pancreatic Neuroendocrine Neoplasms
  Journal of clinical medicine · DOI · Europe PMC
• 2026-04病例报告开放获取
  Merkel cell carcinoma with in-transit metastases: Complete response after intralesional interleukin-2 therapy
  JAAD case reports · DOI · Europe PMC
• 2026-04
  YAP1 Defines an Emergent, Plastic Population of Relapsed SCLC
  Journal of thoracic oncology : official publication of the Internation · 被引 1 · DOI · Europe PMC
• 2026-04病例报告开放获取
  Successful Tarlatamab Rechallenge After Recurrent High-Grade Cytokine Release Syndrome in Chromothripsis-Mediated SCLC: A Case Report
  JTO clinical and research reports · DOI · Europe PMC
• 2026-04综述
  Small cell lung cancer: a therapeutic update in the era of immunotherapy and beyond-a narrative review
  Chinese clinical oncology · DOI · Europe PMC
• 2026-03病例报告开放获取
  Primary pure small cell neuroendocrine carcinoma of the endometrium: a case report
  Journal of medical case reports · DOI · Europe PMC
• 2026-03开放获取
  SEOM-GECOD clinical guideline for cancer of unknown primary (update 2025)
  Clinical & translational oncology : official publication of the Federa · DOI · Europe PMC
• 2026-02综述病例报告开放获取
  Ventricular fibrillation triggered by recurrent hypoglycemia in a patient with insulinoma associated with MEN1: case report and review of literature
  Endocrine journal · DOI · Europe PMC
• 2026-02随机对照试验开放获取
  Everolimus as maintenance therapy in advanced neuroendocrine neoplasms: results from the MAVERIC phase II trial
  The oncologist · DOI · Europe PMC
• 2026-01病例报告开放获取
  Persistently elevated procalcitonin leading to the diagnosis of medullary thyroid carcinoma: a surgical case report
  Journal of surgical case reports · DOI · Europe PMC
• 2026-01综述开放获取
  Artificial Intelligence and Machine Learning in Pediatric Endocrine Tumors: Opportunities, Pitfalls, and a Roadmap for Trustworthy Clinical Translation
  Biomedicines · DOI · Europe PMC

在中国开展的临床试验 12L2

按病名在 ClinicalTrials.gov 检索、并校验研究中心含中国大陆而来。登记状态不等于现在真的能入组——务必按 NCT 号到原站核实，并与主治医生商量。

登记为可入组 4

• 招募中NCT05884255
  An Open-label Phase 3 Study of Lutetium (177Lu) Oxodotreotide Injection in Subjects With Advanced Gastrointestinal Pancreatic Neuroendocrine Tumors.
  III 期 · 干预性 · 2023/07/06Jiangsu HengRui Medicine Co., Ltd.
  中国研究中心 2 个：Shanghai、Tianjin
• 招募中NCT06840821
  Evaluating the Safety, Tolerability, and Preliminary Anti-tumor Activity of MB0151 in Adult Subjects With Advanced Solid Tumors Expressing Somatostatin Receptors
  I 期、II 期 · 干预性 · 2025/05/08Mainline Biosciences (Shanghai) Co., Ltd
  中国研究中心 1 个：Jinan
• 招募中NCT06784752
  Study to Evaluate the Efficacy and Safety of [177Lu]Lu-DOTA-TATE in Patients With Grade 1 and Grade 2 Advanced GEP-NET
  III 期 · 干预性 · 2025/05/30Novartis Pharmaceuticals
  中国研究中心 2 个：Beijing、Shanghai
• 招募中NCT07165886
  Sirolimus for Injection (Albumin Bound) Combined With Octreotide Long-acting Injection in Patients With Metastatic Gastroenteropancreatic Neuroendocrine Tumors
  II 期、III 期 · 干预性 · 2025/08/29CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
  中国研究中心 1 个：Beijing

中国境外的在招试验 28L2

CT.gov 报告命中 28 项，此处取回并展示最近的 15 项。

• 尚未开始招募NCT07661420
  211At-MABG in Adults With Advanced Neuroendocrine Cancers
  I 期 · 干预性 · 2026/08/01University of Pennsylvania
  美国
• 招募中NCT06202066
  Temozolomide and Survivin Long Peptide Vaccine (SurVaxM) for the Treatment of Patients With Progressing Metastatic Neuroendocrine Carcinomas
  II 期 · 干预性 · 2026/07/15Roswell Park Cancer Institute
  美国
• 招募中NCT07635316
  A Study of Treatment Patterns and Outcomes in Gastroenteropancreatic Neuroendocrine Tumor (GEP-NET) Patients
  观察性 · 2026/06/12Novartis Pharmaceuticals
  美国
• 尚未开始招募NCT07488923
  A First-in-human (FIH), Phase 1 Study of ML261, an Autologous Potency Enhanced Anti-DLL3 CAR T Cell Therapy, in Participants With R/R SCLC or Select NECs (SPECTRAL-1)
  I 期 · 干预性 · 2026/06Moonlight Bio, Inc
  美国
• 招募中NCT07278479
  Study of [212Pb]Pb-DOTAM-MAM279 ([212Pb]Pb-MP0712) in Patients With Small Cell Lung Cancer and Other DLL3 Expressing Solid Tumors
  I 期、II 期 · 干预性 · 2026/05/18Molecular Partners AG
  美国
• 招募中NCT06937905
  Tarlatamab vs Standard of Care Chemotherapy in Patients With Pre-treated Advanced, Pulmonary or Gastroenteropancreatic Poorly Differentiated Neuroendocrine Carcinomas (NECs)
  III 期 · 干预性 · 2026/02/06Intergroupe Francophone de Cancerologie Thoracique
  法国
• 招募中NCT07165132
  Study of RYZ401 in Subjects With Solid Tumors Expressing SSTRs.
  I 期 · 干预性 · 2025/12/03RayzeBio, Inc.
  加拿大、美国
• 招募中NCT07006727
  Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors
  I 期 · 干预性 · 2025/10/16Novartis Pharmaceuticals
  加拿大、韩国、美国
• 招募中NCT07150546
  Combination External Radiation and PRRT for Large GI Neuroendocrine Tumors.
  I 期 · 干预性 · 2025/10/14Emory University
  美国
• 招募中NCT07080242
  Evaluating BL-M14D1 in Subjects With Locally Advanced or Metastatic Small Cell Lung Cancer and Neuroendocrine Tumors
  I 期 · 干预性 · 2025/04/28SystImmune Inc.
  美国
• 招募中NCT07302100
  Nutritional Status Assessment in Adult Patients Followed for Gastroenteropancreatic Neuroendocrine Tumors at Strasbourg University Hospital
  观察性 · 2024/12/12University Hospital, Strasbourg, France
  法国
• 招募中NCT06016855
  Surgical Debulking Prior to Peptide Receptor Radionuclide Therapy in Well Differentiated Gastroenteropancreatic Neuroendocrine Tumors
  IV 期 · 干预性 · 2024/05/31Vanderbilt-Ingram Cancer Center
  美国
• 招募中NCT04090034
  Peptide Receptor Radionuclide Therapy (PRRT) for the Treatment of Neuroendocrine Tumors
  观察性 · 2024/03/28Methodist Health System
  美国
• 招募中NCT06256705
  Multi-modal Characterisation of Gastroenteropancreatic Neuroendocrine Tumours (GEP-NETs) Treated With Targeted Radionuclide Therapy (TRT): Prospective Interventional Multicentre National Cohort
  不适用 · 干预性 · 2024/03/25Assistance Publique - Hôpitaux de Paris
  法国
• 招募中NCT05773274
  Comparing Retreatment of 177Lu-DOTATATE PRRT Versus the Usual Treatment in Patients With Metastatic Unresectable Gastroenteropancreatic Neuroendocrine Tumors, NET RETREAT Trial
  II 期 · 干预性 · 2024/01/12National Cancer Institute (NCI)
  加拿大、美国

外部标识与链接