嗜酸细胞性胃肠炎
Eosinophilic gastroenteritis
定义 英文原文（暂无中文）
A rare benign gastrointestinal disease characterized by the presence of abnormal and nonspecific gastro-intestinal (GI) manifestations, associated with an eosinophilic infiltration of the GI tract, which can affect several segments and involve several layers within the GI wall.
别名
嗜酸细胞性胃小肠结肠炎
基本事实
- 遗传方式
- 不适用
- 发病年龄
- 各年龄段
- 患病率
- 1-9 / 100 000
临床表型 21
极常见 99–80%1
- 嗜酸性粒细胞增多症 HP:0001880
常见 79–30%12
- 腹痛 HP:0002027
- 胃肠道异常 HP:0011024
- 过敏性鼻炎 HP:0003193
- 贫血 HP:0001903
- 腹泻 HP:0002014
- 吞咽困难 HP:0002015
- C-反应蛋白水平升高 HP:0011227
- 低蛋白血症 HP:0003073
- 白细胞增多症 HP:0001974
- 吸收不良 HP:0002024
- 脂肪泻 HP:0002570
- 呕吐 HP:0002013
偶见 29–5%8
- 腹水 HP:0001541
- 哮喘 HP:0002099
- 特应性皮炎 HP:0001047
- 水肿 HP:0000969
- 红细胞沉降速度升高 HP:0003565
- 便血 HP:0002573
- 蛋白丢失性肠病 HP:0002243
- 体重减轻 HP:0001824
近两年的全球研究 258L2
2024/08 起在 Europe PMC 检索所得，按发表时间倒序显示最近 20 篇。标题未译成中文——自动翻译需要接入 LLM 服务，尚未引入。
- 2026-08病例报告Multifocal Giant Granular Cell Tumors of the Alimentary Canal With Concurrent Eosinophilic Gastrointestinal Disease
- 2026-07[Analysis of clinical characteristics and factors associated with recurrence in children with eosinophilic gastroenteritis]
- 2026-07Eosinophilic gastroenteritis due to egg allergy in a 70-year-old patient
- 2026-06病例报告开放获取Formaldehyde Allergy Presenting with Anaphylaxis Due to Prolonged Immediate-Type Reaction
- 2026-06综述开放获取Comprehensive insights into the roles of eosinophils in the mucosal immunity of gastrointestinal tract: defenders, destructors, and modulators
- 2026-06Abstract
- 2026-05开放获取Genomics in Equine MEED: Whole-Genome Sequencing and Target Mutation Identification
- 2026-05综述开放获取The Microbiome and Esophageal Disease: Where Are We Now?
- 2026-05开放获取Hypereosinophilia of persistent/unknown cause: a bone marrow-based study integrating WHO-HAEM5 criteria and myeloid next-generation sequencing
- 2026-04病例报告开放获取Cystoisospora belli infection in an immunocompetent patient
- 2026-04系统综述综述开放获取Renal involvement in hypereosinophilic syndrome: a systematic review with narrative synthesis of pathology, diagnosis, and therapy
- 2026-04病例报告开放获取Diagnosis of small bowel obstruction secondary to eosinophilic enteritis using nasointestinal ileus tube and enteroscopy: a case report
- 2026-04综述开放获取Stricturing Diseases of the Gastrointestinal Tract-Current Clinical Practice
- 2026-04病例报告开放获取A case of duodenal strongyloidiasis presenting as a gastric outlet obstruction and endoscopically mimicking malignancy: A case report and mini review of literature
- 2026-04综述开放获取Role of IL-5 in eosinophil-associated diseases and prospects for multi-target therapy
- 2026-04病例报告开放获取Unmasking the Parasite: When Giardiasis Looks Like Gastroenteritis
- 2026-03Peripheral Eosinophilia in a Patient With Subacute Watery Diarrhea
- 2026-03综述开放获取Bridging eosinophilic esophagitis: healthcare transition from pediatric to adult patients
- 2026-03开放获取Segmented filamentous bacteria are associated with disease activity in children with inflammatory bowel disease
- 2026-03病例报告开放获取Upadacitinib-Induced Remission in Multicentric Reticulohistiocytosis: Expanding the Therapeutic Role of JAK Inhibition
在中国开展的临床试验 2L2
按病名在 ClinicalTrials.gov 检索、并校验研究中心含中国大陆而来。登记状态不等于现在真的能入组——务必按 NCT 号到原站核实，并与主治医生商量。
登记为可入组 1
- 招募中NCT07257835Dupilumab Therapy for EGIDs中国研究中心 1 个：Shanghai
其他状态的试验（1 项）
- 进行中·不再招募NCT05583227Efficacy and Safety of Tezepelumab in Patients With Eosinophilic Esophagitis中国研究中心 8 个：Beijing、Guangzhou、Hangzhou、Nanjing、Shanghai、Shenyang 等 8 地
中国境外的在招试验 41L2
这些试验在中国没有研究中心，通常无法直接报名——入组一般要求在当地居住并接受随访。列在这里是因为它另有用处：看清楚全世界正在试哪些药、做到了哪一期、由谁在做。把药名和 NCT 编号记下来去问主治医生，或据此进一步查该药是否已在境外获批、是否有拓展性用药（expanded access）通道。
美国22意大利5法国3荷兰3澳大利亚2Mali1德国1阿根廷1比利时1挪威1加拿大1新西兰1瑞士1英国1另有 2 个国家/地区
CT.gov 报告命中 41 项，此处取回并展示最近的 15 项。
- 尚未开始招募NCT07023380EoE Food Test Pilot Study美国
- 招募中NCT07027826The Esophageal String Test as a Diagnostic Screening Tool for Eosinophilic Esophagitis Among Africans With Dysphagia in Mali and the United StatesMali、美国
- 尚未开始招募NCT07588568A Trial of Upadacitinib for Non-responsive Eosinophilic Esophagitis美国
- 招募中NCT07234825Trial of Partial Enteral Nutrition With Dairy Free Diet in Eosinophilic Esophagitis美国
- 招募中NCT07506746PRospective Registry of Esophageal Motility意大利
- 招募中NCT07227506Utility of Mucosal Impedance Device in Chronic Esophageal Disorders:美国
- 招募中NCT07112378A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic Esophagitis美国
- 招募中NCT07614633Natural History of Eosinophilic Esophagitis in Adult and Pediatric Population意大利
- 尚未开始招募NCT07057986Trans-Cervical and Trans-abdominal Ultrasound for Monitoring Esophageal Thickness in Eosinophilic Esophagitis
- 招募中NCT06972147Prevalence and Description of FIRE (Food Induced Immediate Response of the Esophagus) in the Pediatric Population With Eosinophilic Esophagitis法国
- 招募中NCT07012928Local Clinical and Immunological Responses in Eosinophilic Esophagitis (EoE) Patients, Role of Mucosal Barrier Function and Type II Inflammation荷兰
- 尚未开始招募NCT06995274Umbilical Cord Blood Therapy in a Child With Eosinophilic Duodenitis and Autism Spectrum Disorder: a Case Study
- 招募中NCT05485155Zemaira Eosinophilic Esophagitis Pilot Study美国
- 招募中NCT06817213Patient-Centered Decision Support for Eosinophilic Esophagitis美国
- 招募中NCT06705387Dupilumab Versus Topical Corticosteroid Effectiveness - Comparison in the Treatment of Stenotic EoE美国
外部标识与链接
发现这一页有错误？告诉我 · 邮件主题会自动带上本页的 ORPHA 编号
本页数据来源
- 疾病定义、同义词、基因、表型、流行病学：Orphanet（CC BY 4.0）
- 中文病名：Orphanet 中文包，冻结于 2020-06-01
- 表型中文标签：HPO 简体中文翻译（CHPO 上游成果）