罕见病知识库 RareSeen

胶质母细胞瘤

Glioblastoma

定义 英文原文(暂无中文)

Glioblastomas are malignant astrocytic tumors (grade IV according to the WHO classification).

别名

多形性胶质母细胞瘤

基本事实

遗传方式
多基因/多因素、不适用
发病年龄
各年龄段
患病率
1-9 / 100 000

相关基因 1来自下位疾病

Orphanet 未在本条目上直接标注致病基因。下表由本组所属的下位疾病汇总而来,「来源条目」列给出基因实际标注在哪一个 ORPHA 条目上。

基因名称来源条目
LZTR1leucine zipper like post translational regulator 1ORPHA:251576

临床表型 15

必现 100%1

  • 多形性胶质母细胞瘤 HP:0012174

极常见 99–80%1

  • 细胞形态异常 HP:0025461

常见 79–30%11

  • 脑白质形态异常 HP:0002500
  • 胼胝体形态异常 HP:0001273
  • 神经系统生理功能异常 HP:0012638
  • 脑水肿 HP:0002181
  • 情绪不稳 HP:0000712
  • 疲乏 HP:0012378
  • 头痛 HP:0002315
  • 语言障碍 HP:0002463
  • 肌无力 HP:0001324
  • 瘫痪 HP:0003470
  • 视力丧失 HP:0000572

偶见 29–5%2

  • 记忆障碍 HP:0002354
  • 癫痫发作 HP:0001250

近两年的全球研究 39,619L2

2024/08 起在 Europe PMC 检索所得,按发表时间倒序显示最近 20 篇。标题未译成中文——自动翻译需要接入 LLM 服务,尚未引入。

  • 2026-07
    Ultrasound-triggered platelet vehicles loading fluorescein for targeted sonodynamic therapy of glioblastoma
    Drug delivery · DOI · Europe PMC
  • 2026-07
    Single-cell transcriptome-guided biomimetic magnetothermal hydrogel microspheres for multimodal eradication of residual glioblastoma
    Bioactive materials · DOI · Europe PMC
  • 2026-07
    HSV-1 induced autophagy-associated DPD degradation promotes antitumor efficacy of oncolytic HSV-CD/5-FC in experimental glioblastoma
    Cellular signalling · DOI · Europe PMC
  • 2026-07综述
    Emerging bioactive microneedle platforms for disease management: From cutaneous disorders to systemic therapeutics
    Bioactive materials · DOI · Europe PMC
  • 2026-07
    Trichodermin exhibits potent anti-glioblastoma activity by inducing cell cycle arrest and apoptosis, suppressing invasion, and enhancing temozolomide efficacy
    Journal of enzyme inhibition and medicinal chemistry · DOI · Europe PMC
  • 2026-07
    Exploratory multi-omics links CCL2/TIMP1 axis to immunosuppressive TME in glioblastoma
    Cell cycle (Georgetown, Tex.) · DOI · Europe PMC
  • 2026-07综述
    Biomimetic membrane-coated metal nanoplatforms for enhanced BBB penetration and targeted glioblastoma therapy
    International journal of pharmaceutics: X · DOI · Europe PMC
  • 2026-07病例报告
    The clinical utility of magnetic resonance elastography in differentiating tumor recurrence from pseudoprogression in glioblastoma
    Magnetic resonance imaging · DOI · Europe PMC
  • 2026-07综述
    Genomic and chromosomal Instability: Hidden drivers of Glioblastoma aggressiveness
    Gene · DOI · Europe PMC
  • 2026-07综述
    Gut microbiome-mediated modulation of the glioblastoma tumor microenvironment for enhanced immunotherapy response: Mechanistic insights and future perspectives
    Cellular signalling · DOI · Europe PMC
  • 2026-07
    Synthesis and biological investigation of phenothiazine-based derivatives as potential HDAC6 inhibitors for treatment of glioblastoma multiforme
    Bioorganic & medicinal chemistry letters · DOI · Europe PMC
  • 2026-06综述
    Advances in SEC61G research: from ER translocon subunit to emerging pan-cancer oncogenic roles
    Cancer biology & therapy · DOI · Europe PMC
  • 2026-06开放获取
    Knowledge mapping and research trends of chimeric antigen receptor T-cell immunotherapy in breast cancer: A bibliometric and visual analytics study
    Human vaccines & immunotherapeutics · DOI · Europe PMC
  • 2026-06开放获取
    Health literacy, medication adherence, and quality-of-life scores in Jordanian adults with chronic diseases: a dual analytical study using the long-term conditions questionnaire and the EuroQol five-dimension three-level questionnaire
    The Libyan journal of medicine · DOI · Europe PMC
  • 2026-06开放获取
    Risk stratification for in-hospital mortality in sepsis-associated acute kidney injury patients receiving continuous renal replacement therapy: an interpretable, externally validated machine learning study
    Renal failure · DOI · Europe PMC
  • 2026-06开放获取
    STARD10 promotes progression of HER2+ breast cancer and intracellular lipid metabolism via the cAMP/PKA/CREB1 signaling axis
    Cancer biology & therapy · DOI · Europe PMC
  • 2026-06系统综述综述开放获取
    Predictive value of EGFR amplification and EGFRvIII mutation in EGFR-targeted therapy for recurrent glioblastoma: a systematic review
    CNS oncology · DOI · Europe PMC
  • 2026-06综述开放获取
    Synthetic biology of oncolytic bacteria: Comparative microbial chassis and precise killing strategies
    Toxicology reports · DOI · Europe PMC
  • 2026-06综述开放获取
    Significance of GSH and H<sub>2</sub>S regulation for cancer: an intricate interplay between diet, microbiota, metabolic reprogramming, and immune health
    Redox report : communications in free radical research · DOI · Europe PMC
  • 2026-06开放获取
    Predicting long-term allograft outcomes in kidney transplant recipients using a machine learning approach: a 5-year retrospective cohort study
    Renal failure · DOI · Europe PMC

国家医保药品目录中点名本病的药品 1L2

出自《国家基本医疗保险、生育保险和工伤保险药品目录(2025年)》(医保发〔2025〕33号,2026-01-01 起执行)。下列药品在药品名称或限定支付范围里出现了本病的名称

匹配不到 ≠ 不能报销。目录里只有约一成药品设了限定支付范围,其余按适应症正常使用同样可报销;本区块只能回答「目录有没有点名这个病」,不能回答「这个病有没有药能报销」。各省执行细则、双通道与单独支付范围另有规定,请以当地医保部门口径为准。

  • 伯瑞替尼肠溶胶囊乙类谈判药品
    限:1.具有间质-上皮转化因子(MET)外显子14跳变的局部晚期或转移性非小细胞肺癌患者;2.具有间质-上皮转化因子(MET)扩增的局部晚期或转移性非小细胞肺癌患者;3.既往治疗失败的具有PTPRZ1-MET融合基因的IDH突变型星形细胞瘤(WHO4级)或有低级别病史的胶质母细胞瘤成人患者。

境外已获批用于本病的药物 2L2

欧盟 2 项、美国 0 项。同一药物在两地各批一次的,会分别列出。

「境外已获批」不等于「在中国能用」。中间隔着进口注册、临床急需境外新药通道、海南博鳌乐城国际医疗旅游先行区等几条路径,各有各的条件与费用。这一节能确定地告诉你的只有一件事:这个病在世界范围内已经有获得批准的药物,它叫什么名字。拿这个名字去问主治医生,是下一步最省力的做法。

药名一律保留英文原文,不作翻译——中国的药品通用名与英文名的音译经常不一致,译错会让人去找一个不存在的药。

  • Temodal欧盟1999-01-26
    temozolomide
    官方记录
  • Carmustine medac (previously Carmustine Obvius)欧盟2018-07-18
    carmustine
    官方记录
已获孤儿药资格、尚未获批的在研药物(77 项)

孤儿药资格只是一种监管身份——它意味着监管机构认可这是罕见病用药并给予研发激励,不代表这个药已被证明有效,也不代表将来一定能上市。绝大多数最终不会成药。列在这里是为了看清有哪些方向正在被尝试。

  • Sodium Monomercaptoundecahydro-closo-dodecaborate美国1992-04-15
    For use in boron neutron capture therapy (BNCT) in the treatment of glioblastoma multiforme.
    官方记录
  • Iodine I-131 radiolabeled chimeric MAb tumor necrosis treatment (TNT-1美国1999-02-12
    Treatment of glioblastoma multiforme and anaplastic astrocytoma.
    官方记录
  • Fluorouracil美国2000-06-29
    Treatment of glioblastoma multiforme.
    官方记录
  • Hypericin美国2000-08-03
    Treatment of glioblastoma multiforme.
    官方记录
  • 20-mer oligonucleotide complementary to Akt mRNA美国2004-12-08
    Treatment of glioblastoma
    官方记录
  • 4-[1]benzofuro[3,2-d]pyrimidin-4-yl-N-(1,3-benzodioxol-5-ylmethyl)pipe美国2008-07-30
    Treatment, in combination with radiotherapy and temozolomide chemotherapy, of patients with glioblastoma multiforme.
    官方记录
  • mibefradil美国2009-08-25
    Treatment of glioblastoma multiforme.
    官方记录
  • Varbulin美国2009-11-05
    Treatment of glioblastoma multiforme.
    官方记录
  • dendritic cells pulsed with synthetic peptides derived from antigens M美国2010-06-07
    Treatment of glioblastoma or brain stem glioma
    官方记录
  • cediranib美国2010-12-13
    Treatment of glioblastoma
    官方记录
  • vocimagene amiretrorepvec and flucytosine美国2011-01-12
    Treatment of malignant glioma in addition to glioblastoma multiforme
    官方记录
  • trans sodium crocetinate美国2011-07-21
    Treatment of glioblastoma in conjunction with radiotherapy
    官方记录
  • paclitaxel poliglumex美国2012-09-20
    Treatment of glioblastoma multiforme
    官方记录
  • P140K MGMT transduced human CD34 cells美国2013-01-09
    For bone marrow protection in the treatment of glioblastoma multiforme
    官方记录
  • autologous ex vivo expanded CD4+-enriched leukocytes treated with the 美国2013-09-13
    Treatment of glioblastoma multiforme
    官方记录
  • [a-N-(2'succinyl-paclitaxel)Thr]-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-[epsi美国2014-05-14
    Treatment of glioblastoma multiforme
    官方记录
  • anti-beta1 integrin monoclonal antibody美国2014-08-07
    Treatment of glioblastoma
    官方记录
  • altiratinib美国2014-08-19
    Treatment of glioblastoma multiforme.
    官方记录
  • olaptesed pegol美国2014-08-19
    Treatment of glioblastoma in conjunction with radiotherapy.
    官方记录
  • cannabidiol美国2014-08-20
    Treatment of glioblastoma multiforme
    官方记录
  • aldoxorubicin美国2014-09-24
    Treatment of glioblastoma multiforme
    官方记录
  • 8-(1-Hydroxy-ethyl)-2-methoxy-3-(4-methoxy-benzyloxy)-benzo[c]chromen-美国2015-01-21
    Treatment of glioblastoma multiforme
    官方记录
  • saposin C美国2015-02-03
    Treatment of glioblastoma multiforme
    官方记录
  • autologous tumor cells fused with polyethylene glycol to human allogen美国2015-05-06
    Treatment of glioblastoma
    官方记录
  • chloroquine美国2015-05-20
    Treatment of glioblastoma multiforme.
    官方记录
  • 2-{3-[(3R)-3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-dipheny美国2015-06-16
    Treatment of glioblastoma multiforme.
    官方记录
  • nano-diamino-tetraiodothyroacetic acid美国2015-07-09
    Treatment of glioblastoma multiforme (GBM)
    官方记录
  • nivolumab美国2015-08-27
    Treatment of glioblastoma
    官方记录
  • temozolomide美国2015-11-25
    Treatment glioblastoma multiforme in pediatric patients
    官方记录
  • dodecafluoropentane emulsion (DDFPe)美国2015-12-02
    Radiosensitizer to be used during radiation treatment of glioblastoma multiforme (GBM).
    官方记录
  • 6-{4-[l-(propan-2-yl)piperidin-4-yl]-1,4-diazepan-1-yl}-N-(pyridin-4-y美国2016-02-11
    Treatment of glioblastoma multiforme (GBM).
    官方记录
  • 3-(5-Fluoro-benzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7美国2016-03-29
    Treatment of glioblastoma
    官方记录
  • human recombinant bone morphogenetic protein 4美国2016-05-04
    Treatment of glioblastoma multiforme.
    官方记录
  • combination of disulfiram and copper gluconate美国2016-05-18
    Treatment of glioblastoma multiforme.
    官方记录
  • methimazole and liothyronine sodium美国2016-06-02
    Treatment of glioblastoma multiforme.
    官方记录
  • 7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[美国2016-06-23
    Treatment of glioblastoma.
    官方记录
  • Autologous dendritic cell/tumor antigens美国2016-09-27
    Treatment of glioblastoma multiforme (GBM)
    官方记录
  • EnGeneIC delivery vehicles loaded with doxorubicin and targeted to tum美国2017-02-14
    Treatment glioblastoma multiforme
    官方记录
  • Ritanserin美国2017-05-11
    Treatment of glioblastoma
    官方记录
  • O,O'-Bis({4-[3,5-diiodo-4-(1-methylene-1,2,3-triazol-4-ylmethoxy)pheno美国2017-06-28
    Treatment of glioblastoma multiforme
    官方记录

另有 37 项未列出。

数据来自欧洲药品管理局(EMA)的药品与孤儿药资格公开导出表,以及美国 FDA 孤儿药资格数据库。两边口径不同:欧盟一侧取的是当前状态仍为「已授权」的药品;美国一侧记录的是「曾获批准」这一事实,FDA 的公开表不追踪药物此后是否退市(例如 Relyvrio 于 2024 年撤市,表中仍记为已获批)。请以官方记录页为准。

在中国开展的临床试验 147L2

按病名在 ClinicalTrials.gov 检索、并校验研究中心含中国大陆而来。登记状态不等于现在真的能入组——务必按 NCT 号到原站核实,并与主治医生商量。

登记为可入组 57

  • 招募中NCT03005132
    Integrative Analysis of Human Glioblastoma Multiforme
    观察性 · 2016/01Shanghai 10th People's Hospital
    中国研究中心 1 个:Shanghai
  • 招募中NCT05990244
    Magnetic Resonance Elastography in Glioma: Exploring Tumor Stiffness and Adhesion
    不适用 · 干预性 · 2017/01/01Shengjing Hospital
    中国研究中心 1 个:Shenyang
  • 仅邀请入组NCT03170141
    Immunogene-modified T (IgT) Cells Against Glioblastoma Multiforme
    I 期 · 干预性 · 2017/05/31Shenzhen Geno-Immune Medical Institute
    中国研究中心 1 个:Shenzhen
  • 招募中NCT04267978
    Study of Recombinant Human Endostatin Combined with Temozolomide and Irinotecan in Recurrent Gliomas
    II 期 · 干预性 · 2020/02/13Beijing Sanbo Brain Hospital
    中国研究中心 1 个:Beijing
  • 招募中NCT06595186
    JK-1201I Combined with Adjuvant Temozolomide in Patients with Newly Diagnosed Glioblastoma Multiforme (GBM)
    II 期 · 干预性 · 2022/10/31JenKem Technology Co., Ltd.
    中国研究中心 1 个:Beijing
  • 尚未开始招募NCT05541042
    Radiogenomics in Glioblastoma: Correlation Between Multiparametric Imaging Biomarkers and Genetic Biomarkers
    观察性 · 2022/12/01Henan Provincial People's Hospital
    中国研究中心 1 个:Zhengzhou
  • 尚未开始招募NCT05502991
    Sintilimab (One Anti-PD-1 Antibody) Plus Low-dose Bevacizumab for ctDNA-level-relapse and Clinical-relapse Glioblastoma
    II 期 · 干预性 · 2022/12/11Henan Provincial People's Hospital
    中国研究中心 1 个:Zhengzhou
  • 招募中NCT05957679
    MRE Evaluation for Spinal Cord Tumor Surgery: Stiffness and Adhesion Assessment
    不适用 · 干预性 · 2023/01/01Shengjing Hospital
    中国研究中心 1 个:Shenyang
  • 尚未开始招募NCT05842746
    Elemene Plus Stupp Protocol Versus Stupp Protocol Alone for Newly-diagnosed Glioblastoma
    II 期 · 干预性 · 2023/05Peking Union Medical College Hospital
    中国研究中心 1 个:Beijing
  • 招募中NCT05303519
    SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)
    III 期 · 干预性 · 2023/06/05Nuvation Bio Inc.
    中国研究中心 9 个:Beijing、Changsha、Chengdu、Fuzhou、Guangzhou、Shanghai
  • 招募中NCT05577091
    Tris-CAR-T Cell Therapy for Recurrent Glioblastoma
    I 期 · 干预性 · 2023/09/30Beijing Tiantan Hospital
    中国研究中心 1 个:Beijing
  • 尚未开始招募NCT05540275
    Tislelizumab (One Anti-PD-1 Antibody) Plus Low-dose Bevacizumab for Bevacizumab Refractory Recurrent Glioblastoma
    II 期 · 干预性 · 2023/10/05Henan Provincial People's Hospital
    中国研究中心 1 个:Zhengzhou
  • 招募中NCT07145047
    Clinical Study of Oncolytic Virus in Glioblastoma
    I 期、II 期 · 干预性 · 2023/11/02Mianyang Central Hospital
    中国研究中心 1 个:Mianyang
  • 仅邀请入组NCT06616727
    The Safety and Efficacy of SNC-109 CAR-T Cells Therapy the rGBM
    I 期 · 干预性 · 2023/12/26Shanghai Simnova Biotechnology Co.,Ltd.
    中国研究中心 1 个:Beijing
  • 招募中NCT06220552
    The Efficacy and Safety of Low-dose Radiotherapy Combined With Sintilimab and Temozolomide in Recurrent Glioblastoma
    II 期 · 干预性 · 2023/12/27Fifth Affiliated Hospital, Sun Yat-Sen University
    中国研究中心 1 个:Zhuhai
  • 仅邀请入组NCT06690216
    Evaluation of [18F]AlF-NOTA-PCP2 PET/CT for PD-L1 Detection in Malignant Tumors
    I 期、II 期 · 干预性 · 2024/03/30Man Hu
    中国研究中心 1 个:Jinan
  • 招募中NCT06327451
    Evaluate the Efficacy and Safety of Atorvastatin Combined With Temozolomide in the Treatment of Glioblastoma
    II 期 · 干预性 · 2024/04/01Tianjin Medical University General Hospital
    中国研究中心 1 个:Tianjin
  • 尚未开始招募NCT06368934
    Sub-lobectomy for IDH Wild-type and TERT Promoter Mutant Glioblastoma
    不适用 · 干预性 · 2024/04/08Huashan Hospital
    中国研究中心 1 个:Shanghai
  • 招募中NCT05990556
    Research on the Safety and Efficacy of Blocking Dural Blood Supply in Glioblastoma Patients
    不适用 · 干预性 · 2024/05/11First Affiliated Hospital, Sun Yat-Sen University
    中国研究中心 1 个:Guangzhou
  • 招募中NCT06740955
    Hypofractionated Radiotherapy
    不适用 · 干预性 · 2024/08/13The First Hospital of Jilin University
    中国研究中心 1 个:Changchun
  • 仅邀请入组NCT07130149
    Sonodynamic-Chemoradiotherapy Integration in Glioblastoma
    II 期 · 干预性 · 2024/10/01Yingjuan Zheng
    中国研究中心 1 个:Zhengzhou
  • 招募中NCT06598787
    A Study of BL-B01D1 in Patients With Recurrent Glioblastoma
    II 期 · 干预性 · 2024/10/17Sichuan Baili Pharmaceutical Co., Ltd.
    中国研究中心 1 个:Beijing
  • 招募中NCT06640582
    TIL Therapy Combined With Pembrolizumab for Advanced Brain Cancer Including Gliomas and Meningiomas
    I 期、II 期 · 干预性 · 2024/10/20Essen Biotech
    中国研究中心 1 个:Beijing
  • 招募中NCT06757153
    Safety and Efficacy of NRG-103 Injection in the Treatment of Recurrent Glioblastoma Patients
    早期 I 期 · 干预性 · 2024/12/19Zhongnan Hospital
    中国研究中心 1 个:Wuhan
  • 招募中NCT06936046
    Enhanced Adjuvant Therapy for Newly Diagnosed GBM With Partial Surgical Resection or Short-term Progression
    II 期 · 干预性 · 2025/01/01Second Affiliated Hospital, Zhejiang University, School of Medicine
    中国研究中心 1 个:Hangzhou

另有 32 项未列出。

其他状态的试验(90 项)
  • 已完成NCT00870181
    ADV-TK Improves Outcome of Recurrent High-Grade Glioma
    II 期 · 干预性 · 2008/01Huazhong University of Science and Technology
    中国研究中心 1 个:Beijing
  • 已完成NCT03388372
    Nimotuzumab Plus Radiotherapy With Concomitant and Adjuvant Temozolomide for Cerebral Glioblastoma
    II 期 · 干预性 · 2010/08/18Biotech Pharmaceutical Co., Ltd.
    中国研究中心 5 个:Guangdong、Guangzhou、Shenzhen
  • 状态未知NCT01567202
    Study of DC Vaccination Against Glioblastoma
    II 期 · 干预性 · 2012/03Huashan Hospital
    中国研究中心 1 个:Shanghai
  • 状态未知NCT01637753
    Safety and Efficacy Study of Intracranially Implanted Carmustine to Treat Recurrent Malignant Glioma
    不适用 · 干预性 · 2012/06Shandong Lanjin Pharmaceuticals Co.,Ltd
    中国研究中心 1 个:Guangzhou
  • 状态未知NCT01656980
    Safety and Efficacy Study of Intracranially Implanted Carmustine to Treat Newly Diagnosed Malignant Glioma
    III 期 · 干预性 · 2012/08Shandong Lanjin Pharmaceuticals Co.,Ltd
    中国研究中心 1 个:Beijing
  • 状态未知NCT01765088
    A Phase III Trial on Adjuvant Temozolomide With or Without Interferon-alpha in Newly Diagnosed High-grade Gliomas
    III 期 · 干预性 · 2012/09Sun Yat-sen University
    中国研究中心 1 个:Guangzhou
  • 已完成NCT02122822
    Research for Immunotherapy of Glioblastoma With Autologous Heat Shock Protein gp96
    I 期 · 干预性 · 2013/07Cure&Sure Biotech Co., LTD
    中国研究中心 1 个:Beijing
  • 状态未知NCT01939574
    A Explore Study of Bevacizumab Combined With Conventional Therapy in Glioblastoma
    不适用 · 干预性 · 2013/08Shandong Cancer Hospital and Institute
    中国研究中心 1 个:Jinan
  • 状态未知NCT02047058
    Treatment Response and Prognosis in Glioma Patients: Q Cell and Its Biological Characteristics
    观察性 · 2014/03Nanfang Hospital, Southern Medical University
    中国研究中心 1 个:Guangzhou
  • 状态未知NCT02520635
    Supra-early Post-Surgery Chemotherapy in the Treatment on GBM Patients
    观察性 · 2015/01Beijing Tiantan Hospital
    中国研究中心 1 个:Beijing
  • 已完成NCT02573324
    A Study of ABT-414 in Participants With Newly Diagnosed Glioblastoma (GBM) With Epidermal Growth Factor Receptor (EGFR) Amplification
    III 期 · 干预性 · 2015/01/04AbbVie
    中国研究中心 14 个:Beijing、Changsha、Fuzhou、Guangzhou、Hangzhou、Hefei 等 12 地
  • 状态未知NCT02629757
    A Study on β-elemene as Maintain Treatment for Newly Diagnosed Malignant Gliomas
    III 期 · 干预性 · 2015/04Sun Yat-sen University
    中国研究中心 1 个:Guangzhou
  • 已完成NCT02698280
    Bevacizumab and Nimustine in Patients With Recurrent High Grade Glioma
    II 期 · 干预性 · 2015/07Huashan Hospital
    中国研究中心 1 个:Shanghai
  • 状态未知NCT02910804
    IRDye800CW-BBN PET-NIRF Imaging Guiding Surgery in Patients With Glioblastoma
    早期 I 期 · 干预性 · 2015/11Beijing Tiantan Hospital
    中国研究中心 1 个:Beijing
  • 状态未知NCT05600491
    A Phase III Study of Postoperative Early Temozolomide Treatment Plus STUPP Regimen for Newly Diagnosed GBM Multiforme
    III 期 · 干预性 · 2015/11/08Sun Yat-sen University
    中国研究中心 1 个:Guangzhou
  • 状态未知NCT02663440
    Trial of Hypofractionated Intensity Modulated Radiation Therapy With Temozolomide and Granulocyte-macrophage Colony-stimulating Factor for Patients With Newly Diagnosed Glioblastoma Multiforme
    II 期 · 干预性 · 2016/01Zhejiang Cancer Hospital
    中国研究中心 1 个:Hangzhou
  • 已完成NCT02709616
    Personalized Cellular Vaccine for Glioblastoma (PERCELLVAC)
    I 期 · 干预性 · 2016/03/01Guangdong 999 Brain Hospital
    中国研究中心 1 个:Guangzhou
  • 已完成NCT02808364
    Personalized Cellular Vaccine for Recurrent Glioblastoma (PERCELLVAC2)
    I 期 · 干预性 · 2016/03/01Guangdong 999 Brain Hospital
    中国研究中心 1 个:Guangzhou
  • 已完成NCT03660761
    Apatinib in Recurrent or Refractory Intracranial Central Nervous System Malignant Tumors
    II 期 · 干预性 · 2016/03/03Rongjie Tao
    中国研究中心 1 个:Jinan
  • 已完成NCT02728349
    Tolerance and Pharmacokinetic Study of Chlorogenic Acid to Advanced Glioblastoma
    I 期 · 干预性 · 2016/04/12Sichuan J.Z. Bio-chemical Science and Technology Development Co., Ltd
    中国研究中心 1 个:Beijing
  • 状态未知NCT02844062
    Pilot Study of Autologous Anti-EGFRvIII CAR T Cells in Recurrent Glioblastoma Multiforme
    I 期 · 干预性 · 2016/07Beijing Sanbo Brain Hospital
    中国研究中心 1 个:Beijing
  • 状态未知NCT02937844
    Pilot Study of Autologous Chimeric Switch Receptor Modified T Cells in Recurrent Glioblastoma Multiforme
    I 期 · 干预性 · 2016/07Beijing Sanbo Brain Hospital
    中国研究中心 1 个:Beijing
  • 状态未知NCT02939378
    Ketogenic Diet Adjunctive to Salvage Chemotherapy for Recurrent Glioblastoma:a Pilot Study
    I 期、II 期 · 干预性 · 2016/10Song Lin
    中国研究中心 1 个:Beijing
  • 进行中·不再招募NCT02685605
    Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme
    III 期 · 干预性 · 2016/12/09Universitätsmedizin Mannheim
    中国研究中心 1 个:Beijing
  • 状态未知NCT03347097
    Adoptive Cell Therapy of Autologous TIL and PD1-TIL Cells for Patients With Glioblastoma Multiforme
    早期 I 期 · 干预性 · 2017/01/01Huashan Hospital
    中国研究中心 1 个:Shanghai
  • 已完成NCT05476341
    A Phase I Clinical Trial of Bevacizumab Injection
    I 期 · 干预性 · 2017/04/06Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
    中国研究中心 1 个:Changchun
  • 状态未知NCT03567135
    Temozolomide Plus Anti-angiogenesis Drugs and Radiotherapy as a Treatment for Glioblastoma
    观察性 · 2017/10/01Fuzhou General Hospital
    中国研究中心 1 个:Fuzhou
  • 已完成NCT03050736
    Safety Study of VAL-083 and Radiotherapy in Patients With Newly Diagnosed GBM Having Unmethylated MGMT Expression
    II 期 · 干预性 · 2017/12/17Kintara Therapeutics, Inc.
    中国研究中心 1 个:Guangzhou
  • 状态未知NCT03231501
    HMPL-813 in Treating Patients With Glioblastoma
    I 期 · 干预性 · 2018/01/26Hutchison Medipharma Limited
    中国研究中心 2 个:Hanzhou、Shanghai
  • 状态未知NCT03160599
    Restricted Calorie Ketogenic Diet as a Treatment in Malignant Tumors
    不适用 · 干预性 · 2018/03/01Second Affiliated Hospital of Guangzhou Medical University
    中国研究中心 1 个:Guangzhou
  • 状态未知NCT03392545
    Combination of Immunization and Radiotherapy for Malignant Gliomas (InSituVac1)
    I 期 · 干预性 · 2018/04/01Beijing Tiantan Hospital
    中国研究中心 1 个:Beijing
  • 已完成NCT06562621
    Clinical Study on the Safety and Efficacy of Novel Oncolytic Virus in the Treatment of Recurrent Malignant Glioma
    I 期、II 期 · 干预性 · 2018/08/01Beijing Neurosurgical Institute
    中国研究中心 1 个:Beijing
  • 进行中·不再招募NCT06105619
    A Study of PLB1001 Enteric Capsules in the Treatment of sGBM/IDH Mutant Glioblastoma Patients With the ZM Fusion Gene (FUGEN).
    II 期、III 期 · 干预性 · 2018/10/08Beijing Pearl Biotechnology Limited Liability Company
    中国研究中心 1 个:Beijing
  • 状态未知NCT03734913
    A Phase 1 Study of ZSP1602 in Participants With Advanced Solid Tumors
    I 期 · 干预性 · 2019/01/25Guangdong Zhongsheng Pharmaceutical Co., Ltd.
    中国研究中心 1 个:Changchun
  • 已完成NCT04119674
    Pilot Study of Anlotinib With STUPP Regimen for Patients With Newly Diagnosed Glioblastoma
    I 期、II 期 · 干预性 · 2019/03/19Zhejiang Cancer Hospital
    中国研究中心 1 个:Hangzhou
  • 状态未知NCT04045847
    CD147-CART Cells in Patients With Recurrent Malignant Glioma.
    早期 I 期 · 干预性 · 2019/05/30Xijing Hospital
    中国研究中心 1 个:Xi'an
  • 状态未知NCT04004975
    Clinical Study on the Treatment of Recurrent Glioblastoma With Anlotinib
    I 期、II 期 · 干预性 · 2019/06/25Shandong Cancer Hospital and Institute
    中国研究中心 1 个:Jinan
  • 状态未知NCT03650257
    A Large-scale Research for Immunotherapy of Glioblastoma With Autologous Heat Shock Protein gp96
    II 期 · 干预性 · 2019/08/21Cure&Sure Biotech Co., LTD
    中国研究中心 1 个:Beijing
  • 状态未知NCT04157478
    Addition of Anlotinib Hydrochloride to the Stupp Regimen Versus the Stupp Regimen Alone for Newly Diagnosed Glioblastoma
    II 期 · 干预性 · 2020/01People's Hospital of Guangxi Zhuang Autonomous Region
    中国研究中心 7 个:Guilin、Liuzhou、Nanning、Yulin
  • 已撤回NCT04270461
    NKG2D-based CAR T-cells Immunotherapy for Patient With r/r NKG2DL+ Solid Tumors
    I 期 · 干预性 · 2020/03/17Jiujiang University Affiliated Hospital
    中国研究中心 1 个:Jiujiang

另有 50 项未列出。

中国境外的在招试验 427L2

这些试验在中国没有研究中心,通常无法直接报名——入组一般要求在当地居住并接受随访。列在这里是因为它另有用处:看清楚全世界正在试哪些药、做到了哪一期、由谁在做。把药名和 NCT 编号记下来去问主治医生,或据此进一步查该药是否已在境外获批、是否有拓展性用药(expanded access)通道。

美国93法国15德国12英国10意大利9瑞士8加拿大7荷兰7澳大利亚5比利时5瑞典5丹麦4奥地利3波兰3另有 12 个国家/地区

CT.gov 报告命中 427 项,此处取回并展示最近的 15 项。

  • 尚未开始招募NCT07751744
    Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma
    I 期、II 期 · 干预性 · 2028/04/01Jubilant Therapeutics Inc.
  • 尚未开始招募NCT07546669
    Efficacy of Zoster Vaccination in Glioblastoma Patients
    IV 期 · 干预性 · 2027/01/02University Hospital, Essen
  • 尚未开始招募NCT04373785
    NG101m Adjuvant Therapy in Glioblastoma Patients
    I 期、II 期 · 干预性 · 2027/01/01NeuGATE Theranostics
    美国
  • 尚未开始招募NCT01777919
    Disulfiram/Copper Combination In The Treatment of Newly Diagnosed Glioblastoma Multiform
    II 期 · 干预性 · 2027/01Olympion Medical Center
    希腊
  • 尚未开始招募NCT04933422
    CM93 Treatment in Subjects With Epidermal Growth Factor Receptor (EGFR)-Modified Recurrent Glioblastoma (rGBM)
    I 期 · 干预性 · 2027/01Crimson Biopharm Inc.
  • 尚未开始招募NCT07274787
    Safety And Effectiveness Of NaviFUS System With Bevacizumab In Recurrent Glioblastoma
    不适用 · 干预性 · 2026/12/01University of Cincinnati
    美国
  • 尚未开始招募NCT07579208
    A Phase1 Clinical Trial Evaluating Locoregional Delivery Of Engineered NK Cells Containing IL13Ra And EGFvIII Chimeric Antigen Receptor (CAR), IL-21 Secretion And Deleted TGF-BetaR2 And NR3C1 In Recurrent Glioblastoma
    I 期 · 干预性 · 2026/10/24M.D. Anderson Cancer Center
    美国
  • 尚未开始招募NCT07715097
    Survivin-Targeted Dendritic Cell (DC) Cell Injection for Newly Diagnosed Glioblastoma
    II 期 · 干预性 · 2026/09/30Beijing Tricision Biotherapeutics Inc
  • 尚未开始招募NCT07769918
    Hypoxia-targeted Radiotherapy Boost for GBM
    不适用 · 干预性 · 2026/09/01NYU Langone Health
    美国
  • 尚未开始招募NCT07762716
    Combination Immunotherapy Treatment for Glioblastoma Including BreakVax ImmunoTreatment (Designed and Manufactured Per Patient), Chemotherapy and Anti PD-1 Therapy
    I 期、II 期 · 干预性 · 2026/09BreakBio Corp
    美国
  • 尚未开始招募NCT07620548
    Laser Interstitial Thermal Therapy (LiTT) With Cemiplimab or Other Chemotherapy in Recurrent Glioblastomas
    II 期 · 干预性 · 2026/08/31Washington University School of Medicine
    美国
  • 招募中NCT04903795
    BRiTE - Bispecific T Cell Engager for Patients With Glioblastoma
    I 期 · 干预性 · 2026/08/17Mustafa Khasraw, MBChB, MD, FRCP, FRACP
    美国
  • 尚未开始招募NCT07754734
    STUPP Regimen With or Without Lenvatinib for Newly Diagnosed Glioblastoma With MGMT Promoter Methylation
    II 期 · 干预性 · 2026/08/10Dongguan People's Hospital
  • 尚未开始招募NCT07521657
    Efficacy of Mirdametinib Alone or Combination With Radiotherapy for Germline and Sporadic NF1-Altered High-Grade Glioma
    II 期 · 干预性 · 2026/08/01University of Alabama at Birmingham
    美国
  • 招募中NCT06492486
    Glioma Adaptive Radiotherapy With Development of an Artificial Intelligence Workflow
    II 期 · 干预性 · 2026/07/27Tata Memorial Centre
    印度

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本页数据来源

  • 疾病定义、同义词、基因、表型、流行病学:Orphanet(CC BY 4.0)
  • 中文病名:Orphanet 中文包,冻结于 2020-06-01
  • 表型中文标签:HPO 简体中文翻译(CHPO 上游成果)