成人Still病

定义 英文原文（暂无中文）

A rare inflammatory multisystem disorder characterized clinically by four cardinal signs: fever of unknown origin, arthralgia or arthritis, hyperleucocytosis, and typical skin rash.

别名

Wissler-Fanconi综合征

基本事实

遗传方式

不适用

发病年龄

成年期、老年期

患病率

1-9 / 1 000 000（France）

临床表型 59

近两年的全球研究 107L2

2024/08 起在 Europe PMC 检索所得，按发表时间倒序显示最近 20 篇。标题未译成中文——自动翻译需要接入 LLM 服务，尚未引入。

• 2026-08
  Clinical Features and Outcome Measures Across Still Disease (Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still Disease) Cohorts Worldwide: A Systematic Literature Review
  The Journal of rheumatology · DOI · Europe PMC
• 2026-07
  Acute Adult-Onset Still Disease Presenting as Fever of Unknown Origin and Severe Myalgia in a Resource-Limited Tertiary Hospital in Brazil
  Case reports in medicine · DOI · Europe PMC
• 2026-07
  Examination of HLA-DRB1*15-linked Candidate Antigens in Still Disease With and Without Lung Disease and Drug-Associated Immune Reactions
  The Journal of rheumatology · 被引 1 · DOI · Europe PMC
• 2026-06综述病例报告开放获取
  Successful treatment of idiopathic multicentric Castleman disease with TAFRO and kidney involvement: case report and literature review
  Renal failure · DOI · Europe PMC
• 2026-06开放获取
  Malignancy rates in children, young people and adults with JIA: an observational study using CPRD Aurum
  Rheumatology (Oxford, England) · DOI · Europe PMC
• 2026-05
  Autoinflammatory syndromes in chronic urticaria are rare but clinically distinct: A retrospective cohort study
  JAAD international · DOI · Europe PMC
• 2026-05病例报告开放获取
  Severe Hyperferritinemia in Metabolic Dysfunction-Associated Steatotic Liver Disease With Normal Transferrin Saturation and Polyclonal Hypergammaglobulinemia Mimicking Iron Overload
  Cureus · DOI · Europe PMC
• 2026-04病例报告开放获取
  Autoimmune Progesterone Dermatitis: A Case Report and Review of Literature
  Cureus · DOI · Europe PMC
• 2026-04病例报告开放获取
  Severe Treatment-Refractory Macrophage Activation Syndrome: Hemophagocytic Lymphohistiocytosis Presenting With Neurologic Crisis in Systemic Lupus Erythematosus
  Cureus · DOI · Europe PMC
• 2026-04开放获取
  The Role of Extracorporeal Membrane Oxygenation in Cardiopulmonary Dysfunction Due to Rheumatologic Diseases: A Systematic Review
  ACR open rheumatology · DOI · Europe PMC
• 2026-03开放获取
  Sex-based differences in penicillin allergy labeling among adults in a Canadian ambulatory urgent medicine clinic: a cross-sectional study
  Antimicrobial stewardship & healthcare epidemiology : ASHE · DOI · Europe PMC
• 2026-03病例报告开放获取
  Case Report: Flagellate eruption of adult-onset still disease in an Afro-Caribbean woman: highlighting atypical cutaneous disease in richly pigmented skin
  Frontiers in immunology · DOI · Europe PMC
• 2026-03开放获取
  Proceedings of the 2<sup>nd</sup> Symposium "Autoimmune Diseases -Clinical Unmet Needs in Systemic Autoimmune Diseases Guide Clinical, Translational, and Basic Research"
  Mediterranean journal of rheumatology · DOI · Europe PMC
• 2026-03开放获取
  Reliability and Construct Validity of the Physician's Global Assessment of Lung Disease in Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease
  ACR open rheumatology · DOI · Europe PMC
• 2026-03综述开放获取
  Elucidating the grading intricacies of idiopathic multicentric Castleman disease histopathology: a pathologist's perspective
  American journal of clinical pathology · DOI · Europe PMC
• 2026-02
  A Multifaceted Interplay Among Hemophagocytosis, Interleukin-18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases
  Arthritis & rheumatology (Hoboken, N.J.) · 被引 1 · DOI · Europe PMC
• 2026-02
  A Case of Refractory Adult-Onset Still Disease With Macrophage Activation Syndrome and Pulmonary Alveolar Proteinosis
  The Journal of rheumatology · DOI · Europe PMC
• 2026-02开放获取
  Concurrent Idiopathic Multicentric Castleman Disease with TAFRO and Sjögren's Syndrome in a Young Patient: A Challenging Diagnostic Overlap
  European journal of case reports in internal medicine · DOI · Europe PMC
• 2026-02
  Visualization analysis of the use of traditional Chinese medicine in the diagnosis and treatment of rare diseases in mainland China based on CiteSpace
  Intractable & rare diseases research · DOI · Europe PMC
• 2026-02系统综述
  Clinical Features and Outcome Measures Across Still Disease (Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still Disease) Cohorts Worldwide: A Systematic Literature Review
  The Journal of rheumatology · 被引 1 · DOI · Europe PMC

在中国开展的临床试验 3L2

按病名在 ClinicalTrials.gov 检索、并校验研究中心含中国大陆而来。登记状态不等于现在真的能入组——务必按 NCT 号到原站核实，并与主治医生商量。

登记为可入组 1

• 招募中NCT07191444
  A Study of Firsekibart Versus Anakinra in Adult-Onset Still's Disease
  观察性 · 2025/09/24Ruijin Hospital
  中国研究中心 1 个：Shanghai

中国境外的在招试验 7L2

CT.gov 报告命中 7 项，此处取回并展示最近的 6 项。

• 招募中NCT07517250
  A Study on the Use of Canakinumab Among Familial Mediterranean Fever and Still's Disease Patients
  观察性 · 2026/03/15Novartis Pharmaceuticals
  瑞士
• 招募中NCT07203001
  A Phase II Trial to Evaluate the Clinical Efficacy, Safety and Tolerability of MAS825 in Pediatric and Adult Participants With Still's Disease
  II 期 · 干预性 · 2025/11/03Novartis Pharmaceuticals
  加拿大、法国、德国、意大利、荷兰、西班牙、土耳其、美国
• 招募中NCT04402086
  Rheumatology Patient Registry and Biorepository
  观察性 · 2020/08/04Yale University
  美国
• 招募中NCT03510442
  Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions
  观察性 · 2018/05/21National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
  美国
• 招募中NCT05927454
  Acostill ( RaDiCo Cohort) (RaDiCo Acostill)
  观察性 · 2017/07/11Institut National de la Santé Et de la Recherche Médicale, France
  法国
• 招募中NCT02143986
  Glycosylated Ferritin in Macrophagic Activation Syndromes
  观察性 · 2014/05Brugmann University Hospital
  比利时

外部标识与链接